Brcapro software programs6/12/2023 In these families, multiple members may be affected by different types of cancer, and these cancers often develop at an early age. Genetic mutations that increase cancer risk can be passed down from parents to their children, which can affect families across many generations. The package is available for download for research purposes at. This leads to more accurate risk predictions and ultimately has a high impact on prevention strategies for cancer and clinical decision making. It includes a customizable database with default parameter values estimated from published studies and allows users to select any combinations of genes and cancers for their models, including well-established single syndrome BayesMendel models (BRCAPRO and MMRPRO). We present PanelPRO, a new, open-source R package providing a fast, flexible back-end for multi-gene, multi-cancer risk modeling with pedigree data. Most existing models focus on a few specific syndromes however, recent evidence from multi-gene panel testing shows that many syndromes are overlapping, motivating the development of models that incorporate family history on several cancers and predict mutations for a comprehensive panel of genes. Identifying individuals who are at high risk of cancer due to inherited germline mutations is critical for effective implementation of personalized prevention strategies.
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